Objective: To compare the effects of biliopancreatic diversion (BPD) and laparoscopic gastric banding (LAGB) on insulin sensitivity and secretion markbroyard.com with the effects of laparoscopic gastric plication (P).Methods: A total of 52 obese women (age 30-66 years) suffering from type 2 diabetes mellitus (T2DM) were prospectively recruited into three study groups: 16 BPD; 16 LAGB, and 20 P.Euglycemic clamps and mixed meal tolerance tests were performed before, at 1 month and at 6 months after bariatric surgery.
Beta cell function derived from the meal test parameters was evaluated using mathematical modeling.Results: Glucose disposal per kilogram of fat free mass (a marker of peripheral insulin sensitivity) increased significantly in all groups, especially after 1 month.Basal insulin secretion decreased significantly after all three types of operations, with the most marked decrease after BPD compared with P and LAGB.
Total insulin secretion decreased significantly pomyslnaszycie.com only following the BPD.Beta cell glucose sensitivity did not change significantly post-surgery in any of the study groups.Conclusion: We documented similar improvement in insulin sensitivity in obese T2DM women after all three study operations during the 6-month postoperative follow-up.
Notably, only BPD led to decreased demand on beta cells (decreased integrated insulin secretion), but without increasing the beta cell glucose sensitivity.